Abstract :The manner of the cardiomyocytes asynchronized contraction is a new concept revealing the mechanism of the cardiac contraction manner in physiological condition. The manner of the cardiomyocytes asynchronized contraction refers to that during systole both the sub-endocardium and the mid-myocardium contract while the sub-epicardium relaxes, and during diastole both the sub-endocardium and the mid-myocardium relax while the sub-epicardium contracts in physiological condition. The interruption of the manner of the cardiomyocytes asynchronized contraction may cause various heart diseases, including but not limited to myocardial ischemia/infarction, heart failure, and ventricular arrhythmias. The underlying mechanism is explored. This current review summarizes all recent progresses in the research area of the manner of the cardiomyocytes asynchronized contraction.